We are thrilled to announce our confirmed plenary speakers who will be in presenting at the ICCP450 Brisbane Conference.
Dr Fred Guengerich, Tadashi Inagami Professor of Biochemistry, Vanderbilt University School of Medicine
Dr Guengerich’s research deals with the chemical and biological mechanisms by which chemicals are processed and the relevance to drug development, toxicity and disease, focusing on human P450 enzymes and the molecular basis for substrate and reaction discriminiation. Dr Guengerich is a published author and serves as an associate editor of The Journal of Biological Chemistry. Dr Guengerich has trained 21 graduate students and 137 postdoctoral fellows and has received three Valderbilt mentoring awards as a result, as well as various other awards for his research in the P450 field.
Dr Birger Lindberg Møller, Professor of Plant Biochemistry, Plant Biochemistry Laboratory, University of Copenhagen
Dr Møllers lab has elucidated the catalytic roles of P450s in numerous biosynthetic pathways for plant natural products including cyanogenic glucosides and diterpenoids. Assembly of pathways in dynamic enzyme complexes (metabolons), identification of transcription factors controlling pathway expression, in planta compartmentalized storage of natural products in natural deep eutectic solvents and transfer of the pathways for compound production in heterologous hosts are current focus areas. Dr Møller´s research is supported by an ERC Advanced Grant and by the VILLUM, Novo Nordisk and Lundbeck Foundations.
Dr Irina Pikuleva, PhD, Carl F. Asseff Professor of Ophthalmology, Director of the Visual Sciences Research Center at Case Western Reserve University
Dr. Pikuleva received her PhD degree in Bioorganic Chemistry from the Byelorussian Academy of Sciences followed by postdoctoral training in Biochemistry at Vanderbilt University. In 1999, Dr. Pikuleva became a faculty member in the Department of Pharmacology and Toxicology at the University of Texas Medical Branch and then moved in 2008 to Case Western Reserve University. The two major areas of research in Dr. PIkuleva’s laboratory are studies of cholesterol metabolism in the brain and retina. The ultimate goal of these studies is to identify new therapeutic targets and treatments for diseases of the brain (Alzheimer’s disease) and the eye (age-related macular degeneration and diabetic retinopathy).
Dr Emily Scott, Professor of Medicinal Chemistry, Professor of Pharmacology, The University of Michigan
Dr Scott primarily focuses on research of the structure/function relationships of human cytochrome P450 enzymes. Her lab uses structural biology and biochemical techniques to understand drug metabolism and how to target specific P450 enxymes in disease pathways. Dr Scott’s work has been continuously funded by the National Institute of Health since 2004 and she has received multiple notable awards for her achievements in the P450 field.
Dr Andrew Munro Professor of Molecular Enzymology, School of Chemistry, University of Manchester
Dr. Munro received his PhD in Molecular Microbiology in 1991 from the University of Aberdeen. He moved to the Dept. of Biochemistry at Glasgow University in 1991, where he initiated his work on the P450 BM3 enzyme. He then obtained a Royal Society of Edinburgh Research Fellowship (1996-99) in the Department of Chemistry at the University of Edinburgh, prior to moving to a faculty position at the University of Strathclyde (1999). He was promoted to Senior Lecturer at the University of Leicester (2001) and subsequently to a Readership, and then to a Chair in Biochemistry (2003). In 2005 he moved to the University of Manchester, where he is the Professor of Molecular Enzymology in the School of Chemistry. Dr. Munro’s research has a major focus on protein engineering and the structural/mechanistic analysis of microbial cytochromes P450; including BM3, peroxygenases and P450 enzymes from the human pathogen Mycobacterium tuberculosis. Other recent work has included the development of a new route for pravastatin production (with DSM) and the use of fragment screening methods for the development of inhibitors of key P450 enzymes in M. tuberculosis. Dr. Munro’s research programme has been consistently funded by the BBSRC UK research council.